Since the late twentieth century, Chagas disease gained global attention to suppress the vector burden as a main control strategy in endemic countries.
Therefore, in this study, we adopted PCR diagnosis for molecular confirmation of T. cruzi species for the samples detected as positive under microscopic examination and a subset of microscopic negative samples to seek for the under-reported risk. We conclude that the substantial vector-borne transmission risk still exists in this region; no less than 10% of triatomine bugs are potentially transferable of T. cruzi to humans. In this study, we analyzed the current potential transmission risk of T. cruzi via emerging vector of the region, T. dimidiata. In fact, once there was plenty of reports on the vector prevalence through program-based surveys in the late 1900s, now few investigations focus to evaluate the current situation of vector-borne risk in the Central American region [ 1, 15]. From the recent available studies conducted partially in two villages in El Salvador, the infestation rate was less than 10% in 2011 [ 16]. Our active surveillance nationwide resulted in high infestation rate, possibly resulting from the mentioned purposeful sampling method. Therefore, strengthened surveillance for both vector and human infection is required to truly eliminate the risk of T. cruzi transmission in Central America. The selection of the houses for inspection was based on expert purposeful sampling of the field investigators. The routine surveillance of infected triatomine vector in the country through the Ministry of Health is completed by microscopic examination, mainly due to the shortage of instruments and resources to perform molecular diagnosis. This species was once found most prevalent in the sylvatic areas of Central America but now encountered widely in both rural and urban areas. A nationwide vector survey was conducted in the domestic environment of El Salvador from September 2018 to November 2020. The surveillance focuses on self-reported vector detection and spraying of residual infesting sites of triatomine bugs [ 2]. While the last decade has witnessed significant changes in ecosystem—such as urbanization and replacement of the main vector species—that can possibly affect the vector’s habitation and residual transmission, the up-to-date vector burden in the region has not been evaluated thoroughly due to the cessation of active vector surveillance. The aim of this study was to update the risk of vector-borne Trypanosoma cruzi infection in El Salvador, the top Chagas disease-endemic country in Central America.
MilliporeSigma scientists operating a 200 L Mobius® Single-Use Bioreactor using the VirusExpress® 293 Adeno-Associated Virus Production Platform at the ...
The new platform is an extension of the company's VirusExpress offering, which can reduce process development time by up to 40 percent, according to the company. Suspension culture is amenable to scalable robust manufacturing processes, while being less labor-intensive, according to the company. MilliporeSigmahas launched the VirusExpress 293 Adeno-Associated Virus Production Platform, making it one of the first CDMOs and to provide a full viral vector manufacturing offering including AAV, Lentiviral, CDMO, CTO, and process development.
The finding exposes the danger of older, unpatched bugs, which plague at least 4.5 million devices.
"While this allows organizations to focus on their core business logic and release code faster, this also introduces a security risk in the form of software vulnerabilities," he says. "Once you are aware of the risk, make sure you have the right processes and tools in place that will allow you to effectively take action," he says. "First, many organizations with less mature security programs do not even have visibility into the vulnerabilities they have in their environment," he says. Externally accessible vulnerabilities expected to remain a favorite attack vector for cybercriminals in the future. It is unknown how many of the more than 167,000 applications using this library are running vulnerable versions, according to Vicarius, which published a report detailing the attack path. The tool is used by thousands of Google services, but prior to a September 2021 patch, it housed unsafe and exploitable functions, potentially exposing user input data.
... -- Transformational precision gene delivery company launched out of Versant's Ridgeline Discovery Engine –. -- Vector developing platform for precisely ...
Vector is located in Basel, Switzerland and has a 40-member staff that is expected to increase as the company expands its platform and pipeline of therapeutic candidates. Incorporating cutting-edge platform technologies, from world-class academic research at the University of Zürich, Vector BioPharma uses engineered virus-like particles to achieve cell- and tissue-specific delivery and tunable expression of genes and regulators with unprecedented precision. “We’re thrilled to be working with Lorenz, Andreas and the team to advance Vector’s rationally designed gene delivery technology,” said Alex Mayweg, Ph.D., Managing Director at Versant and a Vector board member. Since the firm’s founding in 1999, more than 85 Versant companies have achieved successful acquisitions or IPOs. For more information, please visit www.versantventures.com. The company is backed by Versant Ventures. For more information, please visit www.vectorbiopharma.com. Versant Ventures is a leading healthcare venture capital firm committed to helping exceptional entrepreneurs build the next generation of great companies. BASEL, Switzerland--( BUSINESS WIRE)-- Versant Ventures today announced the debut of Vector BioPharma AG, a biopharmaceutical company developing a precision gene delivery platform that is devoid of viral genes. In the first half of 2023, Vector expects to have in vivo data for its lead pipeline programs. This compares favorably with conventional viral gene delivery technologies such as AAV that are only capable of packaging 4.7 kb. Lorenz Mayr, Ph.D., CEO. Dr. Mayr is an experienced executive from Bayer, Novartis, AstraZeneca and GE Healthcare, where he led a 2,000 member-strong R&D organization. The platform combines high-capacity virus-like particles with designed, exogenous, high-avidity adapter proteins. Finally, the viral capsid is engineered and shielded from the immune system, providing a safe and stable delivery system that carries complex and multiple gene cassettes with a large genome packaging capacity of up to 36 kb.
Milvus is one of the world's most advanced vector databases, capable of managing massive quantities of both structured and unstructured data to accelerate the ...
Vector BioPharma AG, a biopharmaceutical company developing a precision gene delivery platform devoid of viral genes, has launched with a $30 million Series ...
In the first half of 2023, Vector says it expects to have in vivo data for its lead pipeline programs. Versant Ventures has announced the debut of Vector BioPharma AG, a biopharmaceutical company developing a precision gene delivery platform devoid of viral genes. Vector is located in Basel, Switzerland and has a 40-member staff that is expected to increase as the company expands its platform and pipeline of therapeutic candidates. Because of their drawbacks, there has been strong interest in alternatives to adeno-associated viral (AAV) vectors, such as modified transgenes and a cytomegalovirus-based vector. “We’re thrilled to be working with Lorenz, Andreas and the team to advance Vector’s rationally designed gene delivery technology,” said Alex Mayweg, PhD, Managing Director at Versant and a Vector board member. This compares favorably with conventional viral gene delivery technologies such as AAV that are only capable of packaging 4.7 kb.
Versant Ventures today announced the debut of Vector BioPharma AG, a biopharmaceutical company developing a precision gene delivery platform that is d.
Vector is located in Basel, Switzerland and has a 40-member staff that is expected to increase as the company expands its platform and pipeline of therapeutic candidates. Incorporating cutting-edge platform technologies, from world-class academic research at the University of Zürich, Vector BioPharma uses engineered virus-like particles to achieve cell- and tissue-specific delivery and tunable expression of genes and regulators with unprecedented precision. Since the firm’s founding in 1999, more than 85 Versant companies have achieved successful acquisitions or IPOs. For more information, please visit www.versantventures.com. Versant Ventures is a leading healthcare venture capital firm committed to helping exceptional entrepreneurs build the next generation of great companies. The company is backed by Versant Ventures. For more information, please visit www.vectorbiopharma.com. “We’re thrilled to be working with Lorenz, Andreas and the team to advance Vector’s rationally designed gene delivery technology,” said Alex Mayweg, Ph.D., Managing Director at Versant and a Vector board member. BASEL, Switzerland--( BUSINESS WIRE)--Versant Ventures today announced the debut of Vector BioPharma AG, a biopharmaceutical company developing a precision gene delivery platform that is devoid of viral genes. In the first half of 2023, Vector expects to have in vivo data for its lead pipeline programs. Lorenz Mayr, Ph.D., CEO. Dr. Mayr is an experienced executive from Bayer, Novartis, AstraZeneca and GE Healthcare, where he led a 2,000 member-strong R&D organization. This compares favorably with conventional viral gene delivery technologies such as AAV that are only capable of packaging 4.7 kb. The platform combines high-capacity virus-like particles with designed, exogenous, high-avidity adapter proteins. Finally, the viral capsid is engineered and shielded from the immune system, providing a safe and stable delivery system that carries complex and multiple gene cassettes with a large genome packaging capacity of up to 36 kb.
Most of the gene therapy world centers around viral vectors, but a few biotechs have sprung up in recent years to try and avoid the safety issues that can ...
Vector’s 40-employee team will have technical proof-of-concept data in immuno-oncology and genome editing this year, the company said. The non-viral route has spurred a few new biotechs in recent years. Can you do it?’” the Versant managing director said. Amid a broader biotech bear market, gene therapy startups have been particularly affected, as cash crunches have led to multiple rounds of layoffs. The enhanced payload capacity could attract pharma partners, Mayweg said. “We can do dystrophin or others that are really massive, and that’s no problem.
Vector BioPharma has launched from the biotech startup incubator of Versant Ventures, which is backing the company with a $30 million Series A financing.
Vector isn’t the only biotech taking a so-called gutless approach to genetic medicines. The company expects to have in vivo data for its lead programs in the first half of next year. San Diego-based Relay uses an engineered version of the herpes simplex virus, which it claims offers up to 30 times the capacity of AAV. Relay unveiled a $55 million seed financing last month. Another potential application is a CAR T-therapy in which those cells are produced inside the patient, Mayweg said. Vector BioPharma is taking a different approach with a delivery vehicle that’s like a virus, but devoid of the features that limit viral vectors. Versant’s prior genetic medicines investments include the founding of CRISPR Therapeutics and Graphite Bio.
Vector Biopharma AG has secured a $30 million series A funding commitment from founding investor Versant Ventures to take forward a new gene delivery ...